A New Liquid Chromatographic Method for the Determination of Acid Dissociation Constants.
نویسندگان
چکیده
منابع مشابه
Determination of the acid dissociation constants of the p-sulphonato-calix[4]arene
The acid dissociation constants of the hydroxyl groups in 25, 26, 27, 28-tetrahydroxy-5, 11, 17, 23-tetrasulphonic-calix[4]arene (SC4) were determined at 25οC by a combination of potentiometric and spectrophotometric titration method. The first and second acid dissociation constants (pKa1, pKa2) were found to be 3.19 and 12.1, which demonstrated pKa shift due to intramolecular hydrogen bonding ...
متن کاملA Reversed Phase High Performance Liquid Chromatographic Method for Determination of Rapamycin
Easily degradating and various isomeric forms of rapamycin (Sirolimus) face the determination of this compound to many challenges. In this study, we developed and validated the isocratic reversed phase high performance liquid chromatographic (RP-HPLC) method for rapamycin. Separation was performed on a C8 column (MZ, 15 × 4.6 mm, 5 µm particle size) using methanol:water (80:20 v/v) as the mobil...
متن کاملA Reversed Phase High Performance Liquid Chromatographic Method for Determination of Rapamycin
Easily degradating and various isomeric forms of rapamycin (Sirolimus) face the determination of this compound to many challenges. In this study, we developed and validated the isocratic reversed phase high performance liquid chromatographic (RP-HPLC) method for rapamycin. Separation was performed on a C8 column (MZ, 15 × 4.6 mm, 5 µm particle size) using methanol:water (80:20 v/v) as the mobil...
متن کاملA High-Performance Liquid Chromatographic Assay for the Determination of Losartan in Plasma
A rapid and sensitive HPLC method was developed for determination of losartan in plasma. Losartan was extracted from plasma by a two-step extraction procedure using chloroform as extracting solvent in acidic medium. HPLC analysis was performed on a cyano reversed-phase column using phosphate buffer (pH 4.3), acetonitrile (750:250, v/v) as mobile phase with a flow rate of 0.9 mL/min. Sodium dicl...
متن کاملA New Validated Stability Indicating Liquid Chromatographic Method for the Determination of Agomelatine
Agomelatine is a melatonergic anti-depressant. A stability-indicating high performance liquid chromatographic technique was developed for the determination of Agomelatine in pharmaceutical formulations. Chromatographic separation was achieved on Shimadzu Model CBM-20A/20 Alite, using Zorbax extended-C18 column (150 × 4.6 mm i.d., 5 μm particle size) with a mixture of 0.1% ammonium formate and a...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Analytical Sciences
سال: 1995
ISSN: 0910-6340,1348-2246
DOI: 10.2116/analsci.11.915